Obama sends Congress $3.77 trillion spending plan

President Barack Obama speaks during the ?In Performance at the White House? in the East Room of the White House in Washington, Tuesday, April 9, 2013, a program for a celebration of Memphis Soul Music. (AP Photo/Pablo Martinez Monsivais)

President Barack Obama speaks during the ?In Performance at the White House? in the East Room of the White House in Washington, Tuesday, April 9, 2013, a program for a celebration of Memphis Soul Music. (AP Photo/Pablo Martinez Monsivais)

WASHINGTON (AP) ? President Barack Obama is sending Congress a $3.77 trillion spending blueprint that seeks to achieve an elusive "grand bargain" to tame runaway deficits by raising taxes further on the wealthy and trimming popular benefit programs such as Social Security.

The president's proposal being unveiled Wednesday includes an additional $1.8 trillion in deficit reduction over the next decade, bringing total deficit savings to $4.3 trillion, based on the administration's calculations.

It projects that the deficit for the 2014 budget year, which begins Oct. 1, would fall to $744 billion. That would be the lowest gap between spending and revenue since 2008.

But instead of moving Congress nearer a grand bargain, Obama's proposals so far have managed to anger both Republicans, who are upset by higher taxes, and Democrats upset with cuts to Social Security benefits.

The president's spending and tax plan is two months late. The administration blames the delay on the lengthy "fiscal cliff" negotiations at the end of December and then fights over the March 1 automatic spending cuts.

The president's plan tracks an offer he made to House Speaker John Boehner, R-Ohio, during December's budget negotiations, which Boehner ended up walking away from because of his opposition to higher taxes on the wealthy.

The Obama budget proposal will join competing budget outlines already approved by the Republican-controlled House and the Democratic-run Senate.

Obama's plan is not all about budget cuts. It also includes an additional $50 billion to fund infrastructure investments, including $40 billion in a "Fix It First" effort to provide immediate investments to repair highways, bridges, transit systems and airports nationwide.

Obama's budget would also provide $1 billion to launch a network of 15 manufacturing innovation institutes across the country, and it earmarks funding to support high-speed rail projects.

The president also is proposing establishment of program to offer preschool to all 4-year-olds from low- and moderate-income families, with the money to support the effort coming from increased taxes on tobacco products.

The administration said its proposals to increase spending would not increase the deficit but rather are paid for either by increasing taxes or making deeper cuts to other programs.

Among the proposed cuts, the administration wants to trim defense spending by an additional $100 billion and domestic programs by an extra $100 billion over the next decade.

The budget proposes cutting $400 billion from Medicare and other health care programs over a decade. The cuts would come in a variety of ways, including negotiating better prescription drug prices and asking wealthy seniors to pay more.

It would obtain an additional $200 billion in savings by scaling back farm subsidies and trimming federal retiree programs.

The most sweeping proposal in Obama's budget is a switch in the way the government calculates the annual cost-of-living adjustments for the millions of recipients of Social Security and other government benefit programs. The current method of measuring increases in the consumer price index would be modified to track a process known as chained CPI.

The new method takes into account changes that occur when people substitute goods rising in price with less expensive products. It results in slightly lower annual reading for inflation.

The switch in the inflation formula would cut spending on government benefit programs by $130 billion over 10 years, although the administration said it planned to protect the most vulnerable, including the very elderly. The change would also raise about $100 billion in higher taxes because the current CPI formula is used to adjust tax brackets each year. A lower inflation measure would mean more money taxed at higher rates.

In the tax area, Obama would raise an additional $580 billion by restricting deductions for the top 2 percent of family incomes. The budget would also implement the "Buffett Rule" requiring that households with incomes of more than $1 million pay at least 30 percent of their income in taxes. Charitable giving would be excluded.

Congress and the administration have already secured $2.5 trillion in deficit reduction over the next 10 years through budget reductions and with the end-of-year tax increase on the rich. Obama's plan would bring that total to $4.3 trillion over 10 years.

It is unlikely that Congress will get down to serious budget negotiations until this summer, when the government once again will be confronted with the need to raise the government's borrowing limit or face the prospect of a first-ever default on U.S. debt.

As part of the administration's effort to win over Republicans, Obama will have a private dinner at the White House with about a dozen GOP senators Wednesday night. The budget is expected to be a primary topic, along with proposed legislation dealing with gun control and immigration.

Early indications are that the budget negotiations will be intense. Republicans have been adamant in their rejection of higher taxes, arguing that the $600 billion increase on top earners that was part of the late December agreement to prevent the government from going over the "fiscal cliff" were all the new revenue they will tolerate.

The administration maintains that Obama's proposal is balanced with the proper mix of spending cuts and tax increases.

Obama has presided over four straight years of annual deficits totaling more than $1 trillion, reflecting in part the lost revenue during a deep recession and the government's efforts to get the economy going again and stabilize the financial system.

The Obama budget's $1.8 trillion in new deficit cuts would take the place of the automatic $1.2 trillion in reductions required by a 2011 budget deal. That provision triggered $85 billion in automatic cuts for the current budget year, and those reductions, known as a "sequester," would not be affected by Obama's new budget.

The budget plan already passed by the GOP-controlled House would cut deficits by a total $4.6 trillion over 10 years on top of the $1.2 trillion called for in the 2011 deal. The budget outline approved by the Democratic-controlled Senate tracks more closely to the Obama proposal, although it does not include changes to the cost-of-living formula for Social Security.

___

Associated Press writers Andrew Taylor, Jim Kuhnhenn and Donna Cassata contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-10-US-Obama-Budget/id-b607220273004e79926f2b77e97adc8b

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VIDEO: Meet the Women of 'Defiance'

On an barely recognizable Earth in the not-too-distant future, survivors of a massive war between humans and several alien races struggle to coexist on the new Syfy series Defiance. They do so, relatively peaceably, in the titular frontier town (you might notice it’s built upon the ruins of St. Louis).

Source: http://www.ivillage.com/video-meet-women-defiance/1-a-532832?dst=iv%3AiVillage%3Avideo-meet-women-defiance-532832

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'This Is The End' Cast Plays A Game Of 'Save, Eat, Screw'

Typically when MTV News gets a group of funny guys together (like we did for "The Hobbit"), we like to play a game called "F---, Marry, Kill," but since "This Is the End" is the first movie of the official lead-up to the 2013 MTV Movie Awards, a little something we call MTV Sneak Peek [...]

Source: http://moviesblog.mtv.com/2013/04/09/this-is-the-end-save-eat-screw/

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How to Migrate to a Solid-State Drive Without Reinstalling Windows [UPDATED]

Installing a solid-state drive is one of the best upgrades you can make to your computer, but migrating your Windows installation to a small drive can be tricky, because your data won't necessarily all fit on the drive. Here's how to install an SSD without reinstalling Windows from scratch.

Look familiar? We've posted this before, but the method we used is now out of date. So, we've updated the guide with a newer, easier, and up to date method for migrating all your data. Enjoy!

We've shown you how to migrate from an old drive to a spacious new drive, but when migrating to an SSD, things get a little more complicated. Instead of upgrading to a bigger drive, you're usually migrating to a smaller drive, which means a lot of files?like music, movies, and games?might not all fit on the SSD. You could always do a clean install (without losing any of your data), but why start fresh when you can migrate everything over, just as it is now? Luckily, the migration is pretty easy to pull off, and you should be able to go through the whole process in an afternoon.

Here's the jist of the process: You'll back up your current drive, then delete all of your personal files, like your documents, movies and music. This will make your Windows installation small enough to fit on the SSD. Then, you'll clone your current drive onto the SSD, and completely erase your current drive. From there, you'll move all your user folders?like My Documents, My Music, and so on?back to the original hard drive, and restore all your personal files from the backup. You'll then be able to reap the benefits of an SSDs speed while keeping all your documents and files readily accessible on a second drive.

What You'll Need

There are a number of different ways to go about this, but we've found this to be the easiest and most reliable method. Here's what you'll need:

• Your current hard drive, with Windows installed. For simplicity's sake we'll call this drive?that is, the drive you're migrating from?your "current hard drive" throughout the tutorial.
• A solid-state drive. This is the drive you'll be migrating to. To get a rough idea of how big it should be, head to your current drive, navigate to C:\Users\ and right-click on your user folder. Hit Properties, and mark down how much space that folder takes up. Head to My Computer and note how much space Drive C: has filled up, and subtract your user folder's size from C:'s total. That's how big your SSD needs to be, though I'd give yourself a good deal of wiggle room for future updates and new programs. We'll assume, for the purposes of this guide, that you've already installed your new hard drive and are ready to migrate your data.
• A backup of all your data. Since you can't clone only part of a drive, you'll need to remove your music, movies, and other personal files from your current drive before migrating Windows to the SSD. That means you'll want to back up your data somewhere else?whether that be an external drive, a spare internal drive, or the cloud. Just make sure that data is safe and recoverable, since we'll be restoring it later on.
• EaseUS Todo Backup Free. This is the program we'll be using to migrate your installation. It's easy to use, free, and it can clone partitions from a big drive to a smaller drive, which is crucial for this process (since your SSD is probably smaller than your current hard drive).

A Note for Dual Booters

This guide assumes your main hard drive only has one partition on it, holding Windows and your documents. If you dual boot with Linux, OS X, or another version of Windows and it resides on the same drive, this whole process becomes a bit more complicated. Make extra sure you have a backup before continuing, and tweak the following two steps to the process:

1. In step three, you'll want to click on your Windows partition and clone only that to the SSD instead of cloning the entire disk. Cloning the entire disk would bring all your partitions over, which you won't likely have room for.
2. After step three, you probably won't be able to boot into Windows on your SSD. This is because the Windows bootloader resides on the MBR, not the partition itself. After you've migrated to the SSD, you'll need to insert your Windows installation CD and choose "Repair Your Computer" from the main screen. Choose Startup Repair from the menu, and your computer should reboot a few times and repair the bootloader.

Step One: Defrag and Back Up Your Data

Before you start, you probably want to defragment your disk. Click the Start menu and type in "defrag", hitting Disk Defragmenter when it comes up. Run one last defrag before you continue.

Next, you'll want to make sure everything is backed up in case something goes wrong. You should already be backing up your data regularly, whether to an external drive or with something like CrashPlan, but if you aren't, now's the time to start. Run one last backup before you start the migration process to make sure it's as up to date as possible.

Step Two: Slim Down Your Current Drive

The next thing you need to do is delete files from your main drive until it becomes small enough to fit on your SSD. That means if your SSD is 120GB and your current drive has 260GB of data on it, you'll need to delete 140GB (260GB - 120GB) worth of files before you can migrate. Usually, this can be accomplished by deleting all the music, movies, documents, and other files out of your "My Music", "My Videos", "My Documents", and other user folders. Don't delete the folders themselves, just delete everything inside them. We want to keep the folders intact for later. And remember, we'll be restoring your files later on, so don't worry about deleting stuff you still need. Don't uninstall any programs, unless you want them gone for good. We want to keep these on the SSD so they can benefit from the drive's speed.

Step Three: Migrate to the SSD

Open up EaseUS Todo backup and choose "Clone" from the left-hand sidebar. Click "Disk Clone." Choose your curent hard drive as the source disk, and choose your SSD as the target disk. Check the "Optimize for SSD" box (this is important for getting the best performance possible out of your SSD). Click Next.

EaseUS will begin copying your disk. Check the "Shut down the computer when the operation completed" box, and your computer will turn off when it's done.

If it tells you the source drive is too big, then you haven't deleted enough data. Remember that the size of the SSD?say, 120GB?is not the same as how much space will be available on the SSD after formatting. Once you've hooked up your SSD, check how much space is actually available and make sure your current drive is using less than that amount of space. Even if your source drive is bigger, EaseUS should automatically resize the partitions so they fit on the SSD, as long as your source drive isn't filled with too much data.

Remember, if you have more than one partition on your original drive, you wan to clone the partition, not the drive. That means instead of choosing "Disk Clone," you should choose "Partition Clone," clone your Windows partition to the SSD, and stick in the repair disc when you're done to repair the bootloader.

Step Four: Wipe Your Original Drive

Once the cloning process is complete, turn your computer back on and boot from the SSD (you should have an option to press F12 for a boot menu, or you can change your drives' boot order in your BIOS). Open up Windows Explorer and find your original Windows drive. Right-click on it and choose "Format". A Quick Format is fine here; we just need to clear off all that old data. Make sure you're wiping your original Windows drive and not your backup; if you're unsure, unplug your backup drive first. You don't want to lose any of your data.

Step Five: Move Your User Folders

Now that you've got Windows on your SSD, you need to get all your other files back on your system. You probably don't have enough room to fit it on your SSD, so we're going to store them on your old drive. And, since we can remap the locations of your My Documents, My Music, and other user folders, we can put them on a second drive without Windows even batting an eyelash.

First, head into your old drive (which should now be empty) and create a new folder to house all your user folders. I just called mine "Whitson." Head into C:\Users\[Your User Name] and you should see all your user folders there. Right-click on each one, hit Properties, and go to the Location tab. Click on the Move button, and choose your newly created user folder as the destination. When you're done, you might have a few miscellaneous settings folders left over (like .gtkrc-2.0 or .VirtualBox), which you can leave there. Your Contacts, Desktop, Downloads, Favorites, Links, Documents, Music, Pictures, Videos, Saved Games, and Searches folders should all be on your old drive.

Step Six: Restore Your Personal Files

Lastly, we just need to restore all your personal files. Open up your backup?wherever it may be?and drag your documents, music, pictures, videos, and other files back into your "My Documents", "My Music", "My Pictures", and other user folders that you just moved.

Now, your files will be accessible just as they always were. Even though they're on a new drive, Windows still sees them as your main "My Documents" or "My Music" folders, so you shouldn't have to change much else. You may have a few programs?the text-based todo.txt is a great example?that still use absolute paths (like C:\Users\Documents instead of just searching your "My Documents" folder), so you may have to tweak a few settings to get everything working properly. For the most part, though, everything should work as it did before, and you should have a much faster computer thanks to the SSD.

Proper SSD Maintenance

We've covered proper SSD maintenance before, so I won't go too deeply into it here. In order to have Windows optimize itself for your new SSD, you may need to re-run the Windows Experience Index. Hit the Start menu and type in "Windows Experience", and hit the "Check the Windows Experience Index" option. Click "Re-Run the Assessment" and it should turn off defragmentation and turn on TRIM.

To double check that it all went as expected, head to your Start menu and type "defrag" in the search box. Click on "Disk Defragmenter". Click on "Configure Schedule" and hit "Select Disks". If all went well, Windows will realize it's on an SSD and your SSD won't even be an option in this menu (if you're on Windows 8, it will show up in the list as an SSD instead, and defragmentation will be disabled).

Lastly, we'll want to make sure TRIM is turned on, which keeps your drive from slowing down over time. Open up a Command Prompt and type in:

fsutil behavior query DisableDeleteNotify

It will either give you a 0 or a 1 as a result. If you get a zero, that means TRIM is enabled. If you get a 1, make sure you have a TRIM-compatible SSD?you may have to Google your SSD's model number to find out.

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The process seems very complicated, but if you follow the steps exactly, the whole migration should go off without a hitch. You'll have a super fast-booting machine, programs will launch almost instantaneously, and you'll still have all your personal files easily accessible on another drive.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/FsW6j9x4A0Q/how-to-migrate-to-a-solid+state-drive-without-reinstalling-windows

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The Unintended Consequences of Intended Consequences - John ...

As the worldwide federalization of everything from Cypriot banks accounts to morning after pills continues to sweep across the globe, I?m reminded of a conversation I had with a former general officer.

In 2007, as we talked about what went wrong in Iraq, he told me: ?We had a plan to invade Iraq. They didn?t use it. It was almost as if they purposefully screwed it up.?

His actual language was stronger, but so it went.

I?ve pondered that conversation since then, because the crises that are coming from both the Left and the Right all over the world seem purposeful to me.? They didn?t start with the Iraq War or end with the housing bubble. And they continue today in almost everything that government does from France to our own federal halls of ?justice?.

Whether its handguns or healthcare or housing, everything needs immediate, dire and direct action from the government say government activists- activists who are disguised as policy experts. It?s as if the world only existed because these government policy experts intervened in the Big Bang, creation and the evolution thereto.

Three years into the experiment in national healthcare, before the program is even implemented, Obamacare is already in crisis. Costs are going up, not down. Not everyone will be covered. Private insurance is on its way to extinction. But hey, you?ll still get to pick you own doctor.

Oh, wait: actually no, you won?t. He quit the medical field.

?Six in 10 physicians say that it is likely that many physicians will retire earlier than planned in the next one to three years,? says Deloitte?s 2013 survey of physicians. ?This perception is fairly uniform among all physicians, irrespective of age, gender, or medical specialty. ? ??

It?s almost as if the experts purposefully messed up nationalized healthcare- wink, wink, wonk.

The same is true with monetary policy. We have records amount of liquidity. What we don?t have is monetary velocity. According to the Federal Reserve, the velocity of money is making all-time lows just at time when confidence in our political betters in going lower too.

Coincidence?

Injecting more liquidity won?t make dollars travel through are economy at a more rapid rate. It won?t replace confidence in a political system that can?t get the right result.?? ????

We have an economic system that produces record corporate profits, record stock market returns, record oil prices, but can?t produce jobs or wages.

Source: http://townhall.com/columnists/johnransom/2013/04/10/the-unintended-consequences-of-intended-consequences-n1562980

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AACR news: Rigosertib Phase 1 results lead to disease-focused Phase 2 development

Public release date: 9-Apr-2013
[ | E-mail | Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver

Promising Phase I clinical trial of Rogosertib leads to multi-institutional Phase II trial

Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors. This is the first trial in which orally administered Rigosertib, a dual kinase inhibitor, was studied in solid tumors. Intravenously rigosertib is already in phase 3 clinical trials for myelodysplastic syndrome and pancreatic cancer and oral rigosertib is being studied in a pair of Phase II trials in lower-risk transfusion dependent MDS patients. The drug candidate is being developed by Onconova Therapeutics, Inc., of Pennington, NJ.

Overall, 48 patients were included in the Phase I trial with oral rigosertib, and 7 remained on study for at least six months. Six head and neck cancer patients included in this study had failed platinum-based therapies, and 2 of these patients showed a response to Rigosertib one with the disappearance of lung metastasis and another with greater than 50 percent decrease of liver metastasis. These 2 patients have received oral rigosertib treatment for 98 and 48 weeks.

"The results from the head and neck cancer patients are interesting, revealing that the drug worked in a subset of patients," says Antonio Jimeno, MD, PhD, investigator at the University of Colorado Cancer Center and director of the university's Head and Neck Cancer Medical Oncology Program. "To learn more about the relationship between response and genetic make-up of the tumor, we've been investigating molecular correlates in a surrogate Phase 2 trial in patient-derived animal models of head and neck cancer."

As highlighted in the AACR presentation, genetic analysis of tumor samples from the Phase 1 trial and continuing genetic analysis of animal models, performed at both the Colorado Molecular Correlates Laboratory (CMOCO) and Dr. Jimeno's research laboratory, detected several potential biomarkers, including the genes PIK3CA and PTEN, which are both members of the signaling pathway targeted by the drug. Whole-exome sequencing of patient samples also revealed what Jimeno calls, "a short list of core alterations in genes for further exploration as predictive biomarkers."

"These promising results from human trial combined with relevant animal models established in our laboratories are helping us learn more about this drug and its mechanism of action. Based on these studies, we are initiating an 80-patient, multi-institutional Phase 2 trial," says Jimeno. In this trial, tissue samples from patients will be analyzed by sequencing and using other genomic tools to fully explore the predictive capability of these candidate biomarkers.

"We have seen meaningful activity in a subset of patients in the Phase I trial and we confirmed this in the surrogate animal model," Jimeno says. "The hope is that broad genetic analysis will help identify biomarkers for accurately matching the drug with the right patients in the future."

"It's an exciting time for an exciting drug," Jimeno says.

###

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[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 9-Apr-2013
[ | E-mail | Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver

Promising Phase I clinical trial of Rogosertib leads to multi-institutional Phase II trial

Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors. This is the first trial in which orally administered Rigosertib, a dual kinase inhibitor, was studied in solid tumors. Intravenously rigosertib is already in phase 3 clinical trials for myelodysplastic syndrome and pancreatic cancer and oral rigosertib is being studied in a pair of Phase II trials in lower-risk transfusion dependent MDS patients. The drug candidate is being developed by Onconova Therapeutics, Inc., of Pennington, NJ.

Overall, 48 patients were included in the Phase I trial with oral rigosertib, and 7 remained on study for at least six months. Six head and neck cancer patients included in this study had failed platinum-based therapies, and 2 of these patients showed a response to Rigosertib one with the disappearance of lung metastasis and another with greater than 50 percent decrease of liver metastasis. These 2 patients have received oral rigosertib treatment for 98 and 48 weeks.

"The results from the head and neck cancer patients are interesting, revealing that the drug worked in a subset of patients," says Antonio Jimeno, MD, PhD, investigator at the University of Colorado Cancer Center and director of the university's Head and Neck Cancer Medical Oncology Program. "To learn more about the relationship between response and genetic make-up of the tumor, we've been investigating molecular correlates in a surrogate Phase 2 trial in patient-derived animal models of head and neck cancer."

As highlighted in the AACR presentation, genetic analysis of tumor samples from the Phase 1 trial and continuing genetic analysis of animal models, performed at both the Colorado Molecular Correlates Laboratory (CMOCO) and Dr. Jimeno's research laboratory, detected several potential biomarkers, including the genes PIK3CA and PTEN, which are both members of the signaling pathway targeted by the drug. Whole-exome sequencing of patient samples also revealed what Jimeno calls, "a short list of core alterations in genes for further exploration as predictive biomarkers."

"These promising results from human trial combined with relevant animal models established in our laboratories are helping us learn more about this drug and its mechanism of action. Based on these studies, we are initiating an 80-patient, multi-institutional Phase 2 trial," says Jimeno. In this trial, tissue samples from patients will be analyzed by sequencing and using other genomic tools to fully explore the predictive capability of these candidate biomarkers.

"We have seen meaningful activity in a subset of patients in the Phase I trial and we confirmed this in the surrogate animal model," Jimeno says. "The hope is that broad genetic analysis will help identify biomarkers for accurately matching the drug with the right patients in the future."

"It's an exciting time for an exciting drug," Jimeno says.

###

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[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/uocd-anr040613.php

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Obama's political organization targets senators on gun legislation (Washington Bureau)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/297589590?client_source=feed&format=rss

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